Longevity research has increasingly moved away from searching for a single mechanism of biological aging and toward a multi-system framework — one in which several parallel processes, each with its own molecular logic, contribute to the progressive decline in cellular function that characterizes aging. Three compounds in the active research literature represent different nodes in […]
MOTS-C (Mitochondrial ORF of the 12S rRNA type-c) is a peptide encoded within the mitochondrial genome rather than the nuclear genome — a characteristic that makes it biologically unusual and has driven significant research interest since its discovery in 2015. Unlike most peptides studied in metabolic research, MOTS-c originates within the mitochondria themselves, leading researchers […]
NAD+: Nicotinamide Adenine Dinucleotide Research and Its Role in Cellular Energy Metabolism, DNA Repair, and Aging Biology Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell that has become one of the most heavily studied molecules in longevity research. NAD+ sits at the intersection of metabolism, DNA repair, and aging biology — […]
